Company Name: Genomenon

Job Details: Hiring Remotely in USA Remote Senior level

Job Url: https://builtin.com/job/staff-software-engineer/6825288

Job Description: Our CommunityGenomenon team members are thoughtful, ambitious, and talented folks working together across multiple states and countries to improve the lives of our customers and patients. We have genetic scientists, PhD’s, former clinicians, and talented professionals who are the best at what they do. Our team is mature and mission-driven, we work hard and collaborate as equals. We're looking for sharp people who want to contribute new perspectives to our community and help us curate the entire human genome. We value folks who are comfortable with rapid change and are excited to build a company together.  We are guided by our core values:Always Learning: Approach challenges with curiosity and a growth mindsetData-Driven: Ask a lot of questions and look to the evidence for answersHumbly Confident: Aware of the value that we and others bring to the team Customer & Patient Driven: Put patients and customers first in everything we doTrue Grit:  Embody passion and persistence, and aren’t afraid of hard workOur CompanyGenomenon is an AI-driven, genomics software company. Our mission is to save and improve lives by making genomic information actionable. We organize the world’s genomic knowledge and put it at the fingertips of clinicians to help diagnose and treat patients suffering from rare diseases and cancer, and to help precision medicine companies create targeted therapies for diseases. There are over 7,000 rare diseases affecting nearly 30 million Americans, 95% of which have no treatment. By harnessing AI and human insight, Genomenon's team is revolutionizing genetic medicine and leading a charge against genetic diseases and cancer for clinicians and pharmaceutical pioneers alike. And the adventure has just begun! Join us in championing the spirit of Genomenon, where every data point is a beacon of hope, every insight a catalyst for change, and every person a vital thread in the fabric of progress. /ge.gno.mai.non/source language: ancient Greekverb to come into beingto be born out of neednounthe leader in Genomic IntelligenceAt Genomenon, we are at the forefront of genomics research and innovation, with a mission to accelerate genetic discoveries and improve patient care. About the RoleWe’re looking for a Staff Software Engineer who can lead the modernization of critical legacy systems across our platform. This role goes beyond feature development—it’s about taking a strategic, first-principles approach to rebuilding foundational services that support genomics workflows, AI-powered literature mining, and curated variant data pipelines.This person will work across the stack and across teams, analyzing undocumented codebases, identifying key functionality, and architecting clean, maintainable replacements. You’ll also play a key role in shaping how our team uses AI tooling to increase velocity and deliver long-term value.This is a high-impact role for someone who thrives on technical challenges, system-level thinking, and meaningful cross-functional collaboration. This is a rare opportunity to have outsized technical impact in a mission-driven organization tackling some of the most meaningful problems in precision medicine.Position Responsibilities:Own the analysis, design, and technical execution of key system modernizationsExtract functional requirements from legacy code with high technical debtDesign and implement new systems using first principles and modern cloud-native architectureUse AI tooling (e.g., GitHub Copilot, GPT-based agents) to accelerate safe, maintainable code generationCollaborate closely with product, data science, and engineering to deliver pragmatic solutions that improve platform stability and velocityMentor engineers on best practices for system decomposition, refactoring, and architectureEvaluate and integrate open-source or off-the-shelf tools where appropriateContribute to engineering roadmap and long-term technical strategyAbout YouYou are a thoughtful, pragmatic engineer who thrives on cleaning up complex systems and building robust, scalable solutions from the ground up. You're comfortable navigating messy, undocumented codebases and enjoy collaborating across teams to bring clarity and structure to ambiguity. You embrace modern tools—like AI code assistants—not just to move faster, but to raise the bar for code quality and maintainabilityWhat You'll Bring8+ years of software engineering experience, including 2+ years in a senior/staff-level roleProven success in system modernization, legacy refactoring, and technical debt reductionStrong backend development skills in Python (preferred), Ruby, Go, or C++Experience with PostgreSQL, Elasticsearch, and modern observability/performance tuning practicesProficiency in cloud infrastructure (AWS: ECS, Lambda, S3) and containerization with DockerFamiliarity with orchestration tools like Dagster or AirflowExposure to frontend technologies like ReactJS and JavaScriptComfort with Git, CI/CD pipelines, and writing clear technical documentationEffective use of AI coding tools (e.g., GitHub Copilot, GPT-4) in real-world developmentExcellent communication skills and ability to collaborate across teams and domainsYour ImpactThis is a high-leverage role. Your efforts will:Reduce technical debt across the platformEnable scalable growth of data systems and AI workflowsImprove platform stability and development velocityIncrease engineering team autonomy through clearer architectureShape company-wide modernization strategyNice to HaveExperience migrating apps from Heroku to AWSExposure to genomics, bioinformatics, or scientific data modelsFamiliarity with AI/ML-based systemsExperience with Elasticsearch and observability toolingBackground working in a fast-paced, scaling startup or health tech environmentKnowledge of bioinformatics, pharmacogenomics, or variant interpretation pipelinesWhy Join Us?At Genomenon, you won’t just write code—you’ll modernize systems that help make genomic information actionable. You'll work with smart, humble colleagues, solving real-world problems with real-world impact. This is a team that values practical innovation, autonomy, and curiosity.Our CommitmentThe only way to build a great company is by hiring talented people with diverse backgrounds and rich life experiences. Those experiences contribute to our culture and help us find creative solutions to the tough problems we're solving. Because of this, we are committed to inclusion across race, gender, age, religion, identity, disability, and background in everything we do. Historically, women and people of color are hesitant to apply for a role unless they meet every qualification listed in the job description. If you are uncertain if you're a fit, please apply. We'd rather have one more resume to review than miss the chance to meet amazing talent.