Job Title: Director of Engineering, Clinical Genomics (Remote, US-based)

Company Name: Genomenon

Job Details: Easy,Apply,Be,an,Early,Applicant,Hiring,Remotely,in,USA,Remote,Senior,level

Job Url: https://builtin.com/job/director-engineering-clinical-genomics-remote-us-based/8469202

Job Description: Our CompanyGenomenon is an AI-driven biomedical intelligence company on a mission to save and improve lives by making biomedical information actionable. Rare diseases and cancer affect more than 30 million people in the U.S. alone and hundreds of millions globally, yet most patients still face long diagnostic journeys and limited treatment options. Our goal is clear and ambitious: to deliver the information that shapes diagnosis and treatment for every rare disease and cancer patient.
We sit at the intersection of AI, genomics, and real world evidence. Genomenon transforms the global scientific literature into a literature derived, real world evidence (RWE) engine for precision medicine—combining large-scale AI with expert human curation to deliver clean, clinically actionable datasets. This approach fills critical gaps left by EHR and claims data, especially in rare disease and oncology, by showing how patients actually present, progress, and respond to therapy.
We turn vast, complex biomedical data—spanning genomics, clinical evidence, and scientific literature—into trusted intelligence that helps clinicians make better diagnostic and therapeutic decisions, and supports life sciences organizations in bringing better therapies to market faster.
Our work has real, measurable impact. Genomenon’s platforms and services are used by more than 250 clinical laboratories and pharma organizations worldwide to support diagnostic interpretation, variant curation, and evidence-based decision-making across the drug development lifecycle.
Each year, our technology helps inform care for tens of thousands of patients facing rare, complex, and time-sensitive conditions—reducing uncertainty and delivering answers when they matter most.
What makes Genomenon unique is our ability to support both clinical diagnostics and pharmaceutical innovation on a shared foundation of advanced AI, deep domain expertise, and rigorously curated data.
In the clinic, our solutions directly influence real world patient outcomes.
In pharma, we enable teams to harness literature derived RWE across clinical trial development, regulatory, and commercial workflows—turning fragmented biomedical knowledge into a strategic asset and emerging as the trusted data layer for genomic diagnostics and precision therapeutics.

If you’re motivated by impact, energized by complexity, and excited to help shape the future of rare disease diagnosis and treatment, there’s no better place to do that work.
Genomenon /ge.gno.mai.non/
Source language: ancient GreekVerb
to come into being
to be born out of need
Noun
the leader in genomic intelligence

Our CommunityGenomenon team members are thoughtful, ambitious, and mission-driven professionals working across states and countries. Our team brings together scientists, clinicians, engineers, and commercial leaders who collaborate as equals and learn from one another every day.
We value curiosity, accountability, and people who thrive in fast-moving, high-impact environments.
We are guided by our core values:
Always Learning: Approach challenges with curiosity and a growth mindset
Data-Driven: Ask a lot of questions and look to the evidence for answers
Humbly Confident: Aware of the value that we and others bring to the team
Customer & Patient Driven: Put patients and customers first in everything we do
True Grit:  Embody passion and persistence, and aren’t afraid of hard work

Director of Software Engineering, Clinical GeneticsGenomenon is an AI-driven genomics company. Our mission is to save and improve lives by making genomic information actionable. We organize the world’s genomic knowledge and put it at the fingertips of clinicians and scientists to help diagnose and treat patients suffering from rare diseases and cancer.
Our flagship product, Mastermind, is a genomics intelligence platform that connects patient DNA to the scientific literature, accelerating clinical interpretation and precision medicine. We’re modernizing our commercial and internal software platforms to leverage AI-derived data, scalable APIs, and cloud-native architectures that support both customer-facing applications and internal clinical curation workflows.
This role is software engineering first. While it includes mentoring and light people management, the primary expectation is that you actively design, build, and ship production software. This position is best suited for an experienced, hands-on full stack engineer who enjoys leading by example and staying deeply engaged in day-to-day coding.
Position ResponsibilitiesLead the hands-on technical development of Genomenon’s clinical genetics software, including commercial applications (UI, APIs, and data deliverables) and internal tools supporting genetic curation
Act as a senior individual contributor and technical lead, spending a significant portion of time writing, reviewing, and shipping production code
Serve as the technical lead partner to Product, collaborating on strategic vision, functional requirements, roadmap definition, and sprint planning
Manage and mentor a small, high-impact engineering team (approximately 3 developers), with a focus on technical growth, code quality, and delivery rather than people administration
Design, implement, and review performant, maintainable user interfaces with a strong emphasis on modern UI engineering using React
Build and maintain backend services and APIs using Python and GO, supporting both user-facing applications and downstream data workflows
Develop and maintain CLI scripts, internal tools, and lightweight automation workflows to support engineering, data, and clinical operations
Contribute to system architecture and design decisions as platforms evolve to incorporate AI-derived data, new APIs, and scalable backend services
Establish and reinforce best practices around code quality, testing, documentation, and operational reliability across frontend and backend systems
Balance near-term delivery with long-term technical strategy, proactively identifying opportunities to reduce technical debt and improve scalability
Collaborate closely with data science, clinical curation, DevOps, and product stakeholders to ensure solutions are robust, practical, and well understood

About YouYou are a senior, hands-on software engineer who enjoys building real products and leading through technical contribution. You have recent, meaningful experience writing production code and do not see management as a replacement for engineering, but as a complement to it.
You are comfortable moving between UI development, backend services, scripting, and automation, and you enjoy owning problems end to end. You communicate clearly, mentor thoughtfully, and enjoy translating complex technical systems into tools that support clinicians, scientists, and patients.
You are excited to modernize established software platforms, adopt AI-driven capabilities, and help define the next phase of clinical genetics software through direct technical leadership.
Skills and BackgroundBachelor’s degree in computer science, software engineering, or a related field; advanced degrees are a plus
8+ years of professional software engineering experience, with recent, hands-on development as a core part of your role
Demonstrated experience as a full stack engineer, with strong depth in frontend development and solid backend expertise
Strong UI engineering foundation, including extensive experience building modern web applications with React and related frontend technologies
Proficiency in Python and GO for API development, business logic, and data integration
Experience writing CLI tools, scripts, and basic automation workflows to improve developer productivity and operational efficiency
Experience building and supporting API-driven systems that serve UI applications and downstream data consumers
Solid understanding of data modeling, schema design, and complex domain-driven systems
Prior experience mentoring engineers or acting as a tech lead, with limited but meaningful people management responsibilities
Strong system design skills, with experience evolving or modernizing existing software platforms
Excellent communication and collaboration skills, with comfort working closely with Product and cross-functional stakeholders
Commitment to writing high-quality, well-tested, maintainable software

Nice to HavesExperience working with bioinformatics, genomics, or clinical data systems
Familiarity with basic genetics concepts and clinical interpretation workflows
Experience integrating AI-derived or ML-adjacent systems into production software
Experience modernizing or scaling SaaS platforms in regulated or high-impact domains

Our CommitmentBuilding a great company starts with building a diverse and inclusive team. We believe that people with different backgrounds, perspectives, and life experiences help us solve harder problems and build better solutions.
Genomenon is committed to inclusion across race, gender, age, religion, identity, disability, and background — in how we hire, how we work, and how we lead.
If you’re excited about the role but unsure whether you meet every qualification, we encourage you to apply. We’d rather review one more resume than miss the chance to meet someone exceptional.